Brexit may herald a serious threat to Germany: its negotiating position will reflect that

While Germany would prefer a “soft Brexit”, in which economic repercussions can be staved off by business flexibility, Britain’s exit from the EU creates new opportunities for its renewal. At the same time, should Brexit be the first step toward the disintegration of the EU, Germany will look back to June 2016 as the beginning of its worst nightmare: the return of orthodox, unchecked and dangerous inter-state competition in Europe, writes Jochen Klingler

SMART - IWRM - Sustainable Management of Available Water Resources with Innovative Technologies - Integrated Water Resources Management in the Lower Jordan Rift Valley : Final Report Phase II (KIT Scientific Reports ; 7698)

SMART was a multi-lateral research project with partners from Germany, Israel, Jordan and the Palestinian Territories. The overall goal was to develop a transferable approach for Integrated Water Resources Management (IWRM) in the water shortage region of the Lower Jordan Valley. The innovative aspect addressed all available water resources: groundwater and surface waters, but also wastewater, brackish water and flood water that need to be treated for use

Controlling pH in shake flasks using polymer-based controlled-release discs with pre-determined release kinetics

<p>Abstract</p> <p>Background</p> <p>There are significant differences in the culture conditions between small-scale screenings and large-scale fermentation processes. Production processes are usually conducted in fed-batch cultivation mode with active pH-monitoring and control. In contrast, screening experiments in shake flasks are usually conducted in batch mode without active pH-control, but with high buffer concentrations to prevent excessive pH-drifts. These differences make it difficult to compare results from screening experiments and laboratory and technical scale cultivations and, thus, complicate rational process development. In particular, the pH-value plays an important role in fermentation processes due to the narrow physiological or optimal pH-range of microorganisms. To reduce the differences between the scales and to establish a pH-control in shake flasks, a newly developed easy to use polymer-based controlled-release system is presented in this paper. This system consists of bio-compatible silicone discs embedding the alkaline reagent Na₂CO₃. Since the sodium carbonate is gradually released from the discs in pre-determined kinetics, it will ultimately compensate the decrease in pH caused by the biological activity of microorganisms.</p> <p>Results</p> <p>The controlled-release discs presented here were successfully used to cultivate <it>E. coli </it>K12 and <it>E. coli </it>BL21 pRSET eYFP-IL6 in mineral media with glucose and glycerol as carbon (C) sources, respectively. With glucose as the C-source it was possible to reduce the required buffer concentration in shake flask cultures by 50%. Moreover, with glycerol as the C-source, no buffer was needed at all.</p> <p>Conclusions</p> <p>These novel polymer-based controlled-release discs allowed buffer concentrations in shake flask media to be substantially reduced or omitted, while the pH remains in the physiological range of the microorganisms during the whole cultivation time. Therefore, the controlled-release discs allow a better control of the pH, than merely using high buffer concentrations. The conditions applied here, i.e. with significantly reduced buffer concentrations, enhance the comparability of the culture conditions used in screening experiments and large-scale fermentation processes.</p

La industrialización posible de la vivienda latinoamericana

La industrialización posible de la vivienda latinoamerican

The Crowdsourced Replication Initiative: Investigating Immigration and Social Policy Preferences. Executive Report.

In an era of mass migration, social scientists, populist parties and social movements raise concerns over the future of immigration-destination societies. What impacts does this have on policy and social solidarity? Comparative cross-national research, relying mostly on secondary data, has findings in different directions. There is a threat of selective model reporting and lack of replicability. The heterogeneity of countries obscures attempts to clearly define data-generating models. P-hacking and HARKing lurk among standard research practices in this area.This project employs crowdsourcing to address these issues. It draws on replication, deliberation, meta-analysis and harnessing the power of many minds at once. The Crowdsourced Replication Initiative carries two main goals, (a) to better investigate the linkage between immigration and social policy preferences across countries, and (b) to develop crowdsourcing as a social science method. The Executive Report provides short reviews of the area of social policy preferences and immigration, and the methods and impetus behind crowdsourcing plus a description of the entire project. Three main areas of findings will appear in three papers, that are registered as PAPs or in process